Chan A W, MacFarlane I A, Bowsher D, Campbell J A
Diabetes Centre, Walton Hospital, Liverpool.
J Neurol Neurosurg Psychiatry. 1992 Jan;55(1):56-9. doi: 10.1136/jnnp.55.1.56.
A simple device is described, consisting of 12 weighted 23 gauge disposable needles (0.2 to 5.2 g), for testing sensation in busy diabetic clinics. The pinprick sensory threshold (PPT) is the lightest weighted needle which consistently elicits a sharp sensation. The subjects were 48 healthy controls (hospital staff), 44 diabetic patients without neuropathic symptoms, and 35 diabetic patients with chronic painful neuropathy. In the controls, the mean PPT from the right hand and foot obtained on two test occasions a week apart did not differ significantly. In diabetic patients without symptomatic neuropathy, the mean PPT in the right hand and right foot were significantly higher than in the controls. The diabetic patients with painful neuropathy had clearly increased mean PPT in the right hand and foot compared with controls. Marstock thermal limen in diabetic patients with painful neuropathy correlated significantly with PPT determinations. PPT and thermal thresholds probably give comparable information on small fibre dysfunction in diabetic patients with symptomatic neuropathy. Compared with thermal threshold determinations however, the weighted needle apparatus is inexpensive, simple, and rapid to use.
本文描述了一种简单的装置，它由12根带重物的23号一次性针头（0.2至5.2克）组成，用于在繁忙的糖尿病诊所中测试感觉。针刺感觉阈值（PPT）是始终能引起刺痛感的最轻重量的针头。受试者包括48名健康对照者（医院工作人员）、44名无神经病变症状的糖尿病患者和35名患有慢性疼痛性神经病变的糖尿病患者。在对照者中，相隔一周进行的两次测试中，右手和右脚的平均PPT没有显著差异。在无症状神经病变的糖尿病患者中，右手和右脚的平均PPT显著高于对照者。与对照者相比，患有疼痛性神经病变的糖尿病患者右手和右脚的平均PPT明显升高。患有疼痛性神经病变的糖尿病患者的马尔斯托克热阈与PPT测定值显著相关。PPT和热阈值可能为有症状神经病变的糖尿病患者的小纤维功能障碍提供可比信息。然而，与热阈值测定相比，带重物的针头装置价格低廉、操作简单且使用快速。
