癌症患者的大小纤维型感觉功能障碍
Large and small fibre type sensory dysfunction in patients with cancer.
作者信息
Lipton R B, Galer B S, Dutcher J P, Portenoy R K, Pahmer V, Meller F, Arezzo J C, Wiernik P H
机构信息
Albert Einstein College of Medicine, New York Department of Neurology.
出版信息
J Neurol Neurosurg Psychiatry. 1991 Aug;54(8):706-9. doi: 10.1136/jnnp.54.8.706.
Quantitative sensory testing was used to assess the prevalence of sensory dysfunction in patients with cancer, carefully screened for other risk factors for neuropathy. Large fibre type sensory function was evaluated using vibration threshold (VT) determinations while small fibre type sensory function was assessed by thermal threshold (TT) determinations. Mean VT and TT were significantly elevated in the toes but not the fingers of cancer patients. VT elevations in the toes occurred in 31% of cancer patients and in 6% of control subjects. TT elevations in the toes occurred in 43% of cancer patients and 4% of control subjects. Based on these findings it is concluded that large and small fibre type sensory dysfunction is much more common in carefully screened cancer patients than in control subjects. This sensory dysfunction is most likely to represent a neuropathy related directly or indirectly associated with cancer.
定量感觉测试用于评估癌症患者感觉功能障碍的患病率，这些患者经过仔细筛查以排除其他神经病变风险因素。大纤维型感觉功能通过振动阈值（VT）测定进行评估，而小纤维型感觉功能通过热阈值（TT）测定进行评估。癌症患者脚趾的平均VT和TT显著升高，但手指未出现这种情况。31%的癌症患者脚趾VT升高，而对照组为6%。43%的癌症患者脚趾TT升高，对照组为4%。基于这些发现，可以得出结论，在经过仔细筛查的癌症患者中，大纤维型和小纤维型感觉功能障碍比对照组更为常见。这种感觉功能障碍很可能代表一种与癌症直接或间接相关的神经病变。
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