人肝细胞生长因子刺激人肝癌细胞系HUH-6克隆5细胞的生长。

Human hepatocyte growth factor stimulates the growth of HUH-6 clone 5 human hepatoblastoma cells.

作者信息

Miyazaki M, Gohda E, Tsuboi S, Tsubouchi H, Daikuhara Y, Namba M, Yamamoto I

机构信息

Department of Cell Biology, Okayama University Medical School, Japan.

出版信息

Cell Biol Int Rep. 1992 Feb;16(2):145-54. doi: 10.1016/s0309-1651(06)80108-6.

DOI:10.1016/s0309-1651(06)80108-6

Abstract

The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody.

摘要

研究了人肝细胞生长因子（hHGF）对人肝癌细胞和肝母细胞瘤细胞增殖的影响，hHGF是原代培养大鼠和人肝细胞的一种有效促有丝分裂原。在5种细胞系（HLE、HuH-6克隆5、HuH-7、PLC/PRF/5和Hep G2）中，只有HuH-6克隆5细胞受到重组hHGF的刺激。天然和重组hHGF均导致细胞数量和细胞DNA合成呈剂量依赖性增加。这种刺激被抗hHGF单克隆抗体强烈抑制。

相似文献

1

Human hepatocyte growth factor stimulates the growth of HUH-6 clone 5 human hepatoblastoma cells.人肝细胞生长因子刺激人肝癌细胞系HUH-6克隆5细胞的生长。

Cell Biol Int Rep. 1992 Feb;16(2):145-54. doi: 10.1016/s0309-1651(06)80108-6.

2

[Effects of cisplatin, carboplatin, etoposide and human hepatocyte growth factor on the colony formation of four human liver cancer cell lines].顺铂、卡铂、依托泊苷及人肝细胞生长因子对四种人肝癌细胞系集落形成的影响

Gan To Kagaku Ryoho. 1993 Oct;20(13):1967-72.

3

Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes.天然和重组人肝细胞生长因子都是人和大鼠肝细胞中DNA合成的高效促进剂。

J Clin Invest. 1991 May;87(5):1853-7. doi: 10.1172/JCI115207.

4

Effect of intracellular pH and two growth factors, epidermal growth factor and human hepatocyte growth factor, on DNA synthesis in non-regenerating and regenerating hepatocytes and hepatoma cells.细胞内pH值以及两种生长因子（表皮生长因子和人肝细胞生长因子）对非再生和再生肝细胞及肝癌细胞中DNA合成的影响。

Osaka City Med J. 1994 Dec;40(2):53-69.

5

Effects of protein kinase inhibitors on the mitogenic activity of human hepatocyte growth factor on rat hepatocytes in primary culture.蛋白激酶抑制剂对人肝细胞生长因子在原代培养大鼠肝细胞上的促有丝分裂活性的影响。

Biochem Biophys Res Commun. 1992 May 29;185(1):22-8. doi: 10.1016/s0006-291x(05)80949-0.

6

Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines.人肝细胞生长因子对人肝细胞及肝癌细胞系增殖的影响。

Eur Surg Res. 2004 Sep-Oct;36(5):300-7. doi: 10.1159/000079915.

7

Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells.肝细胞生长因子抑制肝癌细胞的生长。

Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):373-7. doi: 10.1073/pnas.89.1.373.

8

Hepatocyte growth factor stimulates the growth and activates mitogen-activated protein kinase in human hepatoma cells.肝细胞生长因子刺激人肝癌细胞的生长并激活丝裂原活化蛋白激酶。

J Biomed Sci. 1998;5(3):180-4. doi: 10.1007/BF02253467.

9

Biological and immunological properties of human hepatocyte growth factor from plasma of patients with fulminant hepatic failure.暴发性肝衰竭患者血浆中人肝细胞生长因子的生物学和免疫学特性

Biochim Biophys Acta. 1990 Jun 12;1053(1):21-6. doi: 10.1016/0167-4889(90)90020-e.

10

Effects of human HSS on hepatocyte and hepatoma cell proliferation and D-GAL induced acute liver failure.

Chin Med Sci J. 1992 Dec;7(4):197-200.

引用本文的文献

1

Non-alpha-fetoprotein-producing anaplastic hepatoblastoma cell line.非甲胎蛋白产生型间变性肝母细胞瘤细胞系

In Vitro Cell Dev Biol Anim. 1996 Apr;32(4):194-6. doi: 10.1007/BF02722945.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。