Schwartz Liliana, Wolf David, Markus Arie, Wybraniec Sławomir, Wiesman Zeev
Department of Chemical Engineering and The Institutes for Applied Research, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel.
J Agric Food Chem. 2003 Sep 24;51(20):5985-9. doi: 10.1021/jf0342472.
A simple technique was developed for the production of controlled-release systems (CRSs) for pyriproxyfen, an insect growth regulator active against the larvae of Culex pipiens, the most common species of mosquito found in developed countries. The CRSs consisted of a spongy core material encapsulated in a coating of a polyurethane or polyurea hydrogel, into which the active ingredient had been incorporated. The coating also included a surfactant to improve the low solubility in water of pyriproxyfen. The light core material enabled the CRS to float on the water surface, where the mosquitoe larvae are found. The type and amount of the polymeric coating and the amount of surfactant influenced the release profiles into water of the active ingredient. The release profiles of the CRSs were adjusted to the life cycle of the C. pipiens mosquito in order to obtain their optimal activity on the eighth day, which corresponds to the time of larval maturity.
已开发出一种简单技术，用于生产用于吡丙醚的控释系统（CRS），吡丙醚是一种昆虫生长调节剂，对尖音库蚊幼虫具有活性，尖音库蚊是发达国家最常见的蚊种。CRS由包裹在聚氨酯或聚脲水凝胶涂层中的海绵状核心材料组成，活性成分已掺入其中。涂层还包含一种表面活性剂，以改善吡丙醚在水中的低溶解度。轻质核心材料使CRS能够漂浮在发现蚊幼虫的水面上。聚合物涂层的类型和用量以及表面活性剂的用量影响活性成分在水中的释放曲线。对CRS的释放曲线进行调整，使其与尖音库蚊的生命周期相匹配，以便在第八天获得最佳活性，这与幼虫成熟的时间相对应。
