Jambulingam P, Sadanandane C, Boopathi Doss P S, Subramanian S, Zaim M
Vector Control Research Centre (Indian Council of Medical Research), Ministry of Health & Family Welfare, Govt. of India, Indira nagar, Pondicherry 605 006, India.
Acta Trop. 2008 Jul;107(1):20-4. doi: 10.1016/j.actatropica.2008.04.005. Epub 2008 Apr 15.
Pyriproxyfen, 0.5% granular formulation (GR), an insect growth regulator (IGR) was tested against Culex quinquefasciatus larvae and pupae in disused wells, cesspits and drains at the dosages of 0.1, 0.25, and 0.5kg(ai)/ha to determine the most appropriate field dosage. The IGR was found to be effective against C. quinquefasciatus larvae and pupae in all the larval habitats tested. In drains with slow moving water, application of pyriproxyfen 0.5% GR at 0.5kg(ai)/ha resulted in >80% emergence inhibition (EI) of adults for 4 weeks. At 0.1 and 0.25kg(ai)/ha, the EI was always less than 80%. In stagnant drains, the IGR yielded >80% EI for 1-week period at 0.1kg(ai)/ha. At 0.25 and 0.5kg(ai)/ha, the efficacy was 5-10 times higher. In cesspits, the EI was >80% for 6 weeks when pyriproxyfen 0.5% GR was applied at 0.1kg(ai)/ha, for 11 weeks at 0.25kg(ai)/ha and 9 weeks at 0.5kg(ai)/ha. In disused wells treated at the dosage 0.1kg(ai)/ha, there was >80% EI for 15 weeks and at 0.25 and 0.5kg(ai)/ha, the effective duration was about 1.6-1.8 times longer (24-28 weeks). Considering the quantum of IGR required and the cost and also for safety reasons, the low dosage 0.1kg(ai)/ha is recommended as the field dosage to be applied at weekly interval in stagnant drains, 6 weeks interval in cesspits and 15 weeks interval in disused wells. Since pyriproxyfen 0.5% GR has a relatively longer residual effect than the other IGRs the operational cost could be minimized. Pyriproxyfen 0.5% GR could be one of the choices in the chemical control strategy in Integrated Vector Control Programmes.
0.5% 吡丙醚颗粒剂（GR）是一种昆虫生长调节剂（IGR），在废弃水井、污水坑和排水渠中，以0.1、0.25和0.5千克（有效成分）/公顷的剂量对致倦库蚊幼虫和蛹进行了测试，以确定最合适的田间剂量。结果发现，这种IGR对所有测试幼虫栖息地中的致倦库蚊幼虫和蛹均有效。在水流缓慢的排水渠中，以0.5千克（有效成分）/公顷的剂量施用0.5% 吡丙醚颗粒剂，可使成虫羽化抑制率（EI）在4周内超过80%。在0.1和0.25千克（有效成分）/公顷的剂量下，羽化抑制率始终低于80%。在死水排水渠中，0.1千克（有效成分）/公顷的IGR可在1周内使羽化抑制率超过80%。在0.25和0.5千克（有效成分）/公顷的剂量下，药效高出5至10倍。在污水坑中，当以0.1千克（有效成分）/公顷的剂量施用0.5% 吡丙醚颗粒剂时，羽化抑制率在6周内超过80%；以0.25千克（有效成分）/公顷的剂量施用时，羽化抑制率在11周内超过80%；以0.5千克（有效成分）/公顷的剂量施用时，羽化抑制率在9周内超过80%。在以0.1千克（有效成分）/公顷的剂量处理的废弃水井中，羽化抑制率在15周内超过80%；在0.25和0.5千克（有效成分）/公顷的剂量下，有效持续时间约长1.6至1.8倍（24至28周）。考虑到所需IGR的用量、成本以及安全因素，建议将低剂量0.1千克（有效成分） /公顷作为田间剂量，在死水排水渠中每周施用一次，在污水坑中每6周施用一次，在废弃水井中每15周施用一次。由于0.5% 吡丙醚颗粒剂的残留效果比其他IGR相对更长，因此可将运营成本降至最低。0.5% 吡丙醚颗粒剂可能是综合病媒控制计划化学防治策略中的选择之一。
