Tanuma Junko, Ishizaki Azumi, Gatanaga Hiroyuki, Kikuchi Yoshimi, Kimura Satoshi, Hiroe Michiaki, Oka Shinichi
AIDS Clinical Center, International Medical Center of Japan, Tokyo 162-8655, Japan.
Clin Infect Dis. 2003 Oct 1;37(7):e109-11. doi: 10.1086/377609. Epub 2003 Sep 5.
We describe an adult woman infected with human immunodeficiency virus type 1 (HIV-1) who developed dilated cardiomyopathy (DCM) with histologically confirmed mitochondrial damage while receiving anti-HIV-1 combination therapy that included nelfinavir, lamivudine, and zidovudine. DCM resolved after discontinuation of the regimen, and cardiac function remained normal after initiation of treatment with nelfinavir, lamivudine, and abacavir, which indicates that DCM was induced by mitochondrial toxicity, most likely caused by zidovudine.
我们描述了一名感染1型人类免疫缺陷病毒（HIV-1）的成年女性，她在接受包含奈非那韦、拉米夫定和齐多夫定的抗HIV-1联合治疗时出现了扩张型心肌病（DCM），组织学检查证实存在线粒体损伤。停用该治疗方案后DCM症状缓解，在用奈非那韦、拉米夫定和阿巴卡韦重新开始治疗后心脏功能保持正常，这表明DCM是由线粒体毒性诱导的，很可能是由齐多夫定引起的。
