糖尿病中含生长抑素的D细胞的肥大与增生
Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.
作者信息
Orci L, Baetens D, Rufener C, Amherdt M, Ravazzola M, Studer P, Malaisse-Lagae F, Unger R H
出版信息
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1338-42. doi: 10.1073/pnas.73.4.1338.
Abstract
Insulin-, glucagon-, and somatostatin-contianing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin- and glucagon-containing cells were significantly increased in the islets of juvenile-type human diabetics and of streptozotocin diabetic rats.
摘要
通过免疫荧光染色鉴定的含胰岛素、胰高血糖素和生长抑素的细胞，在取自糖尿病和非糖尿病人类及大鼠的胰腺切片中进行形态计量学定量分析。在青少年型人类糖尿病患者和链脲佐菌素诱导的糖尿病大鼠的胰岛中，含生长抑素和胰高血糖素细胞的体积密度和数量均显著增加。
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