Soejima K, Landing B H
Pediatr Pathol. 1986;6(1):25-46. doi: 10.3109/15513818609025923.
Forty patients with cystic fibrosis (CF), including 34 who died above age 10 years without having developed clinical diabetes mellitus and 6 who died with both cystic fibrosis and diabetes mellitus, were studied. The mean age of the female patients with CF but not diabetes was 15.8 +/- 5.6 years; of males without diabetes, 17.2 +/- 6.4 years; of female patients with CF and diabetes mellitus, 20.2 +/- 6.9 years; and of males with CF and diabetes, 21.3 +/- 6.6 years. The mean number of pancreatic islets in microscopic sections for patients with cystic fibrosis but not diabetes was 4.18 +/- 2.76/mm2, and the value for patients with both cystic fibrosis and diabetes mellitus was 2.61 +/- 2.07/mm2. The lowest density of pancreatic islets (1.69 +/- 0.48/mm2) for cystic fibrosis was found in patients with the latest-stage pathologic lesion. Nesidioblastosis (presence of ductuloinsular complexes) was identified in 14 of 38 cystic fibrosis patients, both with and without diabetes mellitus. The pancreatic islets of both diabetic and nondiabetic patients with CF showed hypertrophy; the mean volume of the three largest pancreatic islets for CF only was 0.0117 +/- 0.00657 mm3 and that for cystic fibrosis and diabetes was 0.00795 +/- 0.00599 mm3, both values being larger than normal. Ratios of the amounts of islet endocrine cells, A cells, B cells, and D cells, were determined by peroxidase--anti-peroxidase labeled antibody staining. The B cells composed 43.0% of endocrine cell mass in cystic fibrosis alone and 30.1% in cystic fibrosis with diabetes mellitus, which were lower than normal proportions. The D cell values, 11.9% in cystic fibrosis and 15.1% in cystic fibrosis with diabetes mellitus, on the other hand, were greater than normal ratios.
对40例囊性纤维化（CF）患者进行了研究，其中包括34例10岁以上死亡且未患临床糖尿病的患者以及6例死于囊性纤维化合并糖尿病的患者。未患糖尿病的CF女性患者平均年龄为15.8±5.6岁；未患糖尿病的男性患者平均年龄为17.2±6.4岁；患CF合并糖尿病的女性患者平均年龄为20.2±6.9岁；患CF合并糖尿病的男性患者平均年龄为21.3±6.6岁。未患糖尿病的CF患者显微镜切片中胰岛的平均数量为4.18±2.76个/mm²，而患CF合并糖尿病的患者该数值为2.61±2.07个/mm²。在病理病变处于最晚阶段的CF患者中发现胰岛密度最低（1.69±0.48个/mm²）。在38例CF患者（包括患糖尿病和未患糖尿病的）中，有14例发现了胰岛细胞增殖症（存在导管胰岛复合体）。患CF的糖尿病患者和非糖尿病患者的胰岛均显示肥大；仅患CF的患者三个最大胰岛的平均体积为0.0117±0.00657mm³，患CF合并糖尿病患者的为0.00795±0.00599mm³，这两个数值均大于正常水平。通过过氧化物酶-抗过氧化物酶标记抗体染色测定胰岛内分泌细胞、A细胞、B细胞和D细胞数量的比例。仅患CF时，B细胞占内分泌细胞总量的43.0%，患CF合并糖尿病时占30.1%，均低于正常比例。另一方面，D细胞的比例在仅患CF时为11.9%，患CF合并糖尿病时为15.1%，均高于正常比例。
