Mitra S, Ghosh L, Chakrabarty P, Biswas M, Bhattacharyya F K, Ghosh D K
Indian Institute of Chemical Biology, Department of Immunochemistry, Calcutta.
J Med Microbiol. 1992 Apr;36(4):283-7. doi: 10.1099/00222615-36-4-283.
Epinephrine and norepinephrine inhibit attachment of Leishmania donovani promastigotes to cultured hamster peritoneal macrophages. The inhibition was significant at catecholamine concentrations of 10(-4) and 10(-5) M and occurred when they were added to the cell mixtures, or after pre-treatment of either macrophages or parasites. Inhibition of attachment after pre-treatment was less marked than when the catecholamines were added to parasite-cell mixtures. Similar results were obtained with dibutyryl cyclic AMP, cholera toxin, theophylline, and cadaverine which raise intracellular cyclic AMP (cAMP). Pretreatment of parasites or macrophages with the bioamines elevated the intracellular cAMP concentration. It is suggested that the inhibitory effect on the host-parasite interaction is mediated through cAMP.
肾上腺素和去甲肾上腺素可抑制杜氏利什曼原虫前鞭毛体与培养的仓鼠腹膜巨噬细胞的附着。在儿茶酚胺浓度为10^(-4)和10^(-5) M时，这种抑制作用显著，且当它们添加到细胞混合物中，或在巨噬细胞或寄生虫预处理后均会出现。预处理后的附着抑制作用不如将儿茶酚胺添加到寄生虫 - 细胞混合物时明显。用二丁酰环磷腺苷、霍乱毒素、茶碱和尸胺处理也得到了类似结果，这些物质可提高细胞内的环磷腺苷（cAMP）水平。用生物胺预处理寄生虫或巨噬细胞可提高细胞内cAMP浓度。提示对宿主 - 寄生虫相互作用的抑制作用是通过cAMP介导的。
