Takashima S, Morimoto S, Tomiyama N, Takeuchi N, Ikezoe J, Kozuka T
Department of Radiology, Osaka University Medical School, Japan.
J Clin Ultrasound. 1992 Feb;20(2):99-109. doi: 10.1002/jcu.1870200203.
Ultrasonography and sialography of parotid glands were prospectively performed on 30 patients with Sjogren syndrome and follow-up ultrasonography was done on 12 patients. Ultrasonography revealed multiple hypoechoic areas (MHA) 2 mm to 5 mm in diameter within the glands in 43% of the patients with intermediate severity of the disease, either homogeneous or slightly nonhomogeneous parotid glands in patients with early stage of the disease, and marked nonhomogeneous glands in patients with advanced diseases. Follow-up ultrasonography showed MHA in one patient, reduction in nonhomogeneity in another three, and no interval changes in the remaining cases. Pathologic studies suggested that MHA represent enlarged parotid lobules replaced by lymphocytic infiltration. We suggest that MHA are characteristic of Sjogren syndrome and that ultrasonography is useful in following the course of the disease and response to treatment.
对30例干燥综合征患者前瞻性地进行了腮腺超声检查和涎腺造影检查，并对其中12例患者进行了超声随访。超声检查发现，疾病中度严重的患者中43%的腺体内部存在直径2毫米至5毫米的多个低回声区（MHA），疾病早期患者的腮腺呈均匀或稍不均匀状态，而疾病晚期患者的腺体则明显不均匀。超声随访显示，1例患者出现MHA，另外3例患者的不均匀性降低，其余病例无间隔期变化。病理研究表明，MHA代表被淋巴细胞浸润替代的肿大腮腺小叶。我们认为MHA是干燥综合征的特征，超声检查有助于跟踪疾病进程和治疗反应。
