Nagey D A, Pupkin M J, MacKenna J, Schomberg D W, Crenshaw C
Am J Obstet Gynecol. 1976 May 15;125(2):249-55. doi: 10.1016/0002-9378(76)90602-5.
A physiologic model of the dynamics of fetoplacental unit dehydroepiandrosterone (HDEA) to estrogen conversion is presented. A mathematical representation of this model is included. The model is used in Part II to determine the rate constant of DHEA to estrogen conversion and to successfully identify those fetuses in jeopardy from placental insufficiency within the population studied. This presentation permits critical comprehension of the model without extensive mathematical background.
本文提出了一个胎儿-胎盘单位脱氢表雄酮（HDEA）向雌激素转化动力学的生理模型。文中包含了该模型的数学表达式。在第二部分中，该模型用于确定脱氢表雄酮向雌激素转化的速率常数，并成功识别出所研究人群中因胎盘功能不全而处于危险中的胎儿。本文的阐述使读者无需具备广泛的数学背景就能对该模型有深入理解。
