Shimada S, Cutting G, Uhl G R
Laboratory of Molecular Neurobiology, ARC/NIDA, Baltimore, Maryland.
Mol Pharmacol. 1992 Apr;41(4):683-7.
Xenopus oocyte expression of the recently cloned gamma-aminobutyric acid (GABA) rho 1 receptor subunit cDNA yields a pharmacologic profile characteristic of the GABAc responses described by Johnston [Benzodiazepine/GABA Receptors and Chloride Channels. Receptor Biochemistry and Methodology (R. W. Olsen and J. C. Venter, eds), Vol. 5. Alan R. Liss, New York, 57-71 (1986)] and the responses to retinal mRNA recently reported in the Xenopus expression system [Proc. Natl. Acad. Sci. USA 88:4318-4322 (1991)]. A rationale for defining GABA rho 1 as forming a GABAc receptor is discussed.
最近克隆的γ-氨基丁酸（GABA）ρ1受体亚基cDNA在非洲爪蟾卵母细胞中表达，产生了约翰斯顿所描述的GABAc反应的药理学特征[《苯二氮卓/GABA受体与氯离子通道。受体生物化学与方法学》（R.W.奥尔森和J.C.文特尔编），第5卷。阿兰·R·利斯出版社，纽约，第57 - 71页（1986年）]，以及最近在非洲爪蟾表达系统中报道的对视网膜mRNA的反应[《美国国家科学院院刊》88:4318 - 4322（1991年）]。本文讨论了将GABAρ1定义为形成GABAc受体的理论依据。
