Smith N M, Telfer S M, Byard R W
Department of Histopathology, Adelaide Children's Hospital, South Australia.
Pediatr Pathol. 1992 Mar-Apr;12(2):185-90. doi: 10.3109/15513819209023294.
Submandibular salivary glands and tracheobronchial glands from postmortem examinations of 89 cases of sudden infant death syndrome (SIDS) and 67 age-matched control cases in which death was not due to SIDS were examined for the presence of intranuclear and intracytoplasmic inclusions characteristic of cytomegalovirus (CMV). Inclusions were identified by light microscopy and confirmed by immunohistochemistry in submandibular glands of 5 of 89 (5.6%) SIDS and 6 of 67 (8.9%) non-SIDS patients. No inclusions were found in tracheobronchial glands. No further cases were detected following immunoperoxidase studies and examination of multiple levels of inflamed submandibular glands. Brain stem glial knots were found in only one case with CMV inclusions, which was a non-SIDS case with death due to congenital immunodeficiency. We have found no difference in the incidence of CMV inclusions in the submandibular gland between SIDS and age-matched non-SIDS infants. No strong association between CMV inclusions in salivary gland and brain stem glial knots was present.
对89例婴儿猝死综合征（SIDS）尸检的下颌下唾液腺和气管支气管腺，以及67例年龄匹配的非SIDS死亡对照病例的相应腺体进行检查，以查找具有巨细胞病毒（CMV）特征的核内和胞质内包涵体。通过光学显微镜鉴定包涵体，并在89例SIDS患者中的5例（5.6%）和67例非SIDS患者中的6例（8.9%）的下颌下腺中通过免疫组织化学得以证实。在气管支气管腺中未发现包涵体。在进行免疫过氧化物酶研究和检查多个层面的炎症下颌下腺后，未检测到更多病例。仅在1例有CMV包涵体的病例中发现脑干神经胶质小结，该病例为非SIDS病例，死于先天性免疫缺陷。我们发现SIDS婴儿与年龄匹配的非SIDS婴儿在下颌下腺中CMV包涵体的发生率没有差异。唾液腺中的CMV包涵体与脑干神经胶质小结之间不存在强关联。
