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Regulatory elements that control the lineage-specific expression of myoD.

作者信息

Goldhamer D J, Faerman A, Shani M, Emerson C P

机构信息

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111.

出版信息

Science. 1992 Apr 24;256(5056):538-42. doi: 10.1126/science.1315077.

DOI:10.1126/science.1315077
PMID:1315077
Abstract

The molecular basis of skeletal muscle lineage determination was investigated by analyzing DNA control elements that regulate the myogenic determination gene myoD. A distal enhancer was identified that positively regulates expression of the human myoD gene. The myoD enhancer and promoter were active in myogenic and several nonmyogenic cell lines. In transgenic mouse embryos, however, the myoD enhancer and promoter together directed expression of a lacZ transgene specifically to the skeletal muscle lineage. These data suggest that during development myoD is regulated by mechanisms that restrict accessibility of myoD control elements to positive trans-acting factors.

摘要

相似文献

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Regulatory elements that control the lineage-specific expression of myoD.
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2
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