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[神经系统兴奋性阈值不同的大鼠品系对神经源性暴露的差异敏感性]

[The differential sensitivity to a neurotigenic exposure of rat strains differing by the threshold of nervous system excitability].

作者信息

Shiriaeva N V, Vaĭdo A I, Lopatina N G, Kulagin D A, Glushchenko T S, Taranova N P

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Jan-Feb;42(1):137-43.

PMID:1316003
Abstract

The influence was studied of 15-days stressing on the appearance of stable neurosis-like state of rats lines, selected by the excitability of the nervous system. Unconditioned and conditioned components of behaviour were tested: pain sensitivity, behaviour in the open field, level of "anxiety", passive and active defensive avoidance. Differential reactivity was shown of the rats lines to prolonged stressing, depending on the genetically determined level of the nervous system functional state. Interlinear differences in dynamics of the development of neurosis-like state were established.

摘要

研究了对根据神经系统兴奋性挑选出的大鼠品系施加15天应激对稳定的类神经症状态出现的影响。测试了行为的非条件和条件成分:疼痛敏感性、旷场中的行为、“焦虑”水平、被动和主动防御性回避。结果表明,大鼠品系对长期应激的反应存在差异,这取决于遗传决定的神经系统功能状态水平。确定了类神经症状态发展动态中的品系间差异。

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