Yu A M, Song R L, Yu Z, Chen Y P, Wang F Z, Na L X, Xie G L, Yang M J
Department of Pathology, China Medical University, Liaoning.
Arch Pathol Lab Med. 1992 May;116(5):490-4.
The cause of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) remains unknown. It is characterized by acute onset, severe constitutional symptoms, cervical or generalized lymphadenopathy, lymphopenia, and polyclonal hypergammaglobulinemia, all of which are highly suggestive of a viral origin. Using immunohistochemical methods, employing murine monoclonal antibody as the primary antibody, we detected human cytomegalovirus antigen in the lymph nodes of eight of 11 patients with AILD. Cytomegalovirus DNA was also detected in the peripheral blood mononuclear cells by DNA dot hybridization in all five of the patients with AILD who were tested using this technique. None of the lymph nodes from the 11 patients stained positive for the rubella virus antigen. Based on the above evidence and the similarity of the immunologic abnormalities found in both AILD and cytomegalovirus infection, the possible role of cytomegalovirus as one of the causative agents for AILD is proposed.
伴蛋白异常血症的血管免疫母细胞性淋巴结病（AILD）的病因尚不清楚。其特征为急性起病、严重的全身症状、颈部或全身性淋巴结病、淋巴细胞减少和多克隆高丙种球蛋白血症，所有这些都高度提示病毒起源。我们使用鼠单克隆抗体作为一抗，采用免疫组化方法，在11例AILD患者中的8例淋巴结中检测到了人巨细胞病毒抗原。通过DNA斑点杂交，在接受该技术检测的所有5例AILD患者的外周血单个核细胞中也检测到了巨细胞病毒DNA。11例患者的淋巴结中均未检测到风疹病毒抗原呈阳性染色。基于上述证据以及在AILD和巨细胞病毒感染中发现的免疫异常的相似性，提出了巨细胞病毒作为AILD致病因子之一的可能作用。
