急性和慢性单相性炎性脱髓鞘性多发性神经病（IDP）的自然病程。对266例病例的回顾性分析。

Natural course of acute and chronic monophasic inflammatory demyelinating polyneuropathies (IDP). A retrospective analysis of 266 cases.

作者信息

Gibbels E, Giebisch U

机构信息

Neurological Department, University of Cologne, Germany.

出版信息

Acta Neurol Scand. 1992 Apr;85(4):282-91. doi: 10.1111/j.1600-0404.1992.tb04045.x.

DOI:10.1111/j.1600-0404.1992.tb04045.x

PMID:1316709

Abstract

The present study analyses one of the largest IDP series published as yet: 266 cases, hospitalised between 1950 and 1983, conventionally treated and uniformly supervised. There was GBS in 84%, chronic IDP in 13%, polyneuritis cranialis in 1.5%, Miller Fisher and predominantly sensory neuropathy in 0.8% each. Numerous features including preceding events, course and outcome have been investigated. Latencies between onset and maximal deficit lacked (expected) bimodality. Sensory involvement was severe, mortality (18%) and maximal disability (20% requiring ventilation) high, autonomic dysfunction (71%) prominent. Statistical comparison of various features confirmed old age, rapid onset and need for ventilation as unfavorable predicting factors. However, preceding infection, bulbar paralysis and onset of paresis in proximal muscles evolved as unfavorable prognostic features as well.

摘要

本研究分析了迄今为止发表的最大的一组炎性脱髓鞘性多发性神经病（IDP）病例系列：266例患者，于1950年至1983年间住院，接受传统治疗并受到统一监管。其中格林-巴利综合征（GBS）占84%，慢性IDP占13%，颅神经多神经炎占1.5%，米勒-费雪综合征和以感觉神经病变为主的病例各占0.8%。对包括前驱事件、病程和预后等众多特征进行了研究。起病至最大功能缺损之间的潜伏期缺乏（预期的）双峰分布。感觉受累严重，死亡率（18%）和最大残疾率（20%需要通气支持）较高，自主神经功能障碍（71%）显著。对各种特征的统计学比较证实，高龄、起病迅速和需要通气是不利的预测因素。然而，前驱感染、延髓麻痹以及近端肌肉轻瘫的起病同样也是不良的预后特征。