Steele F R, Washburn T, Rieger R, O'Tousa J E
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
Cell. 1992 May 15;69(4):669-76. doi: 10.1016/0092-8674(92)90230-a.
The Drosophila retinal degeneration C (rdgC) gene is required to prevent light-induced retinal degeneration. Molecular analysis shows that the rdgC transcription unit encodes a novel serine/threonine protein phosphatase. Amino acids 153-393 define a domain that has 30% identity with the catalytic domains of types 1, 2A, and 2B serine/threonine protein phosphatases. A putative regulatory domain is appended that contains multiple potential Ca(2+)-binding sites or "EF hand motifs." Thus, the analysis suggests that the rdgC protein is a novel type of serine/threonine protein phosphatase that is directly regulated by Ca2+. rdgC is expressed in the visual systems of the fly, as well as in the mushroom bodies of the central brain.
果蝇视网膜变性C（rdgC）基因是预防光诱导视网膜变性所必需的。分子分析表明，rdgC转录单位编码一种新型丝氨酸/苏氨酸蛋白磷酸酶。氨基酸153 - 393定义了一个与1型、2A和2B型丝氨酸/苏氨酸蛋白磷酸酶的催化结构域具有30%同一性的结构域。后面附加了一个推定的调节结构域，其包含多个潜在的Ca(2+)结合位点或“EF手基序”。因此，分析表明rdgC蛋白是一种新型的丝氨酸/苏氨酸蛋白磷酸酶，可直接受Ca2+调节。rdgC在果蝇的视觉系统以及中枢脑的蘑菇体中表达。
