Allalunis-Turner M J, Barron G M, Day R S, Fulton D S, Urtasun R C
Cross Cancer Institute, Edmonton, Alberta, Canada.
Int J Radiat Oncol Biol Phys. 1992;23(2):339-43. doi: 10.1016/0360-3016(92)90751-3.
The inherent radiosensitivity of early passage cells derived from 22 patients with tumors of glial origin has been determined using a clonogenic assay system. The mean (+/- SD) surviving fraction at 2 Gy was 0.37 +/- 0.22 (range = 0.02-0.87). No correlation between inherent radiosensitivity and tumor cell plating efficiency or intracellular glutathione was observed. Tumor cells that were both resistant to nitrosoureas and expressed the Mer+ phenotype did not differ significantly in their radiosensitivity as compared to cells that were repair deficient (Mer-) and sensitive to nitrosoureas. Initial clinical follow-up suggests that factors in addition to inherent tumor cell radiosensitivity, such as performance status and age, continue to be the most important determinants of the response of patients with primary brain tumors to radiotherapy.
使用克隆形成测定系统测定了来自22例神经胶质源性肿瘤患者的早期传代细胞的固有放射敏感性。2 Gy时的平均（±标准差）存活分数为0.37±0.22（范围=0.02 - 0.87）。未观察到固有放射敏感性与肿瘤细胞接种效率或细胞内谷胱甘肽之间的相关性。与对亚硝基脲修复缺陷（Mer-）且敏感的细胞相比，对亚硝基脲耐药且表达Mer+表型的肿瘤细胞在放射敏感性上无显著差异。初步临床随访表明，除了肿瘤细胞固有放射敏感性之外的因素，如体能状态和年龄，仍然是原发性脑肿瘤患者对放疗反应的最重要决定因素。
