司帕沙星、其他喹诺酮类药物及四环素类药物对沙眼衣原体的体外和体内活性
In vitro and in vivo activities of sparfloxacin, other quinolones, and tetracyclines against Chlamydia trachomatis.
作者信息
Nakata K, Maeda H, Fujii A, Arakawa S, Umezu K, Kamidono S
机构信息
Department of Urology, School of Medicine, Kobe University, Japan.
出版信息
Antimicrob Agents Chemother. 1992 Jan;36(1):188-90. doi: 10.1128/AAC.36.1.188.
Abstract
Sparfloxacin was more potent than other quinolones (tosufloxacin, lomefloxacin, ciprofloxacin, ofloxacin, fleroxacin, enoxacin, and norfloxacin) and as potent as minocycline and doxycycline in activity against Chlamydia trachomatis in vitro and in vivo. Sparfloxacin was more bactericidal than minocycline against C. trachomatis D/UW-3/Cx.
摘要
司帕沙星在体外和体内对沙眼衣原体的活性方面比其他喹诺酮类药物（妥舒沙星、洛美沙星、环丙沙星、氧氟沙星、氟罗沙星、依诺沙星和诺氟沙星）更强，且与米诺环素和多西环素的活性相当。司帕沙星对沙眼衣原体D/UW-3/Cx的杀菌作用比米诺环素更强。
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