新型喹啉衍生物对生殖系统病原体的活性。
Activities of new quinoline derivatives against genital pathogens.
作者信息
Aznar J, Caballero M C, Lozano M C, de Miguel C, Palomares J C, Perea E J
出版信息
Antimicrob Agents Chemother. 1985 Jan;27(1):76-8. doi: 10.1128/AAC.27.1.76.
Abstract
The in vitro activities of four quinoline carboxylic acids against 48 strains of Neisseria gonorrhoeae, 10 of Chlamydia trachomatis, and 32 of Ureaplasma urealyticum were compared. Ciprofloxacin was the most active against N. gonorrhoeae and C. trachomatis but had poor bactericidal activity against U. urealyticum, whereas ofloxacin showed the most bactericidal activity against U. urealyticum but was less active than ciprofloxacin against the two former pathogens. Norfloxacin and enoxacin were less active against all the studied pathogens.
摘要
比较了四种喹啉羧酸对48株淋病奈瑟菌、10株沙眼衣原体和32株解脲脲原体的体外活性。环丙沙星对淋病奈瑟菌和沙眼衣原体活性最强，但对解脲脲原体的杀菌活性较差，而氧氟沙星对解脲脲原体的杀菌活性最强，但对前两种病原体的活性低于环丙沙星。诺氟沙星和依诺沙星对所有研究的病原体活性较低。
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