Lin T J, Liu G T, Liu Y, Xu G Z
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Free Radic Biol Med. 1992;12(5):347-51. doi: 10.1016/0891-5849(92)90083-s.
It was found that salvianolic acid A (Sai A) has potent antioxidant activity. The effects of Sai A on adriamycin-induced heart mitochondrial toxicity of rats in vitro and on adriamycin antitumor activity are investigated in this article. Malondialdehyde (MDA) formation and membrane rigidification of rat heart mitochondria intoxicated with adriamycin were significantly reduced by Sai A. In the electron spin resonance (ESR) studies, Sai A has no significant effect on the formation of adriamycin semiquinone radicals (AQ.), while hydroxyl radicals generated by electron transfer from AQ. to H2O2 were scavenged by Sai A dose-dependently. On the other hand, Sai A was shown to have no effects on the antitumor activity of adriamycin in cultured L1210 ascitic tumor cells and in mice with P388 ascite tumor. These results indicate that Sai A protects against adriamycin induced heart mitochondrial toxicity of rats, while Sai A has no antagonizing effect on the antitumor activity of adriamycin.
研究发现，丹酚酸A（Sai A）具有强大的抗氧化活性。本文研究了Sai A对阿霉素诱导的大鼠心脏线粒体毒性的体外影响以及对阿霉素抗肿瘤活性的影响。Sai A显著降低了阿霉素中毒的大鼠心脏线粒体中丙二醛（MDA）的形成和膜硬化。在电子自旋共振（ESR）研究中，Sai A对阿霉素半醌自由基（AQ.）的形成没有显著影响，而由AQ.向H2O2电子转移产生的羟基自由基则被Sai A剂量依赖性地清除。另一方面，在培养的L1210腹水肿瘤细胞和患有P388腹水肿瘤的小鼠中，Sai A对阿霉素的抗肿瘤活性没有影响。这些结果表明，Sai A可保护大鼠免受阿霉素诱导的心脏线粒体毒性，而Sai A对阿霉素的抗肿瘤活性没有拮抗作用。
