Branski D, Hurvitz H, Halevi A, Klar A, Navon P, Weidenfeld J
Department of Pediatrics, Bikur Cholim General Hospital, Jerusalem, Israel.
J Pediatr Gastroenterol Nutr. 1992 Feb;14(2):173-6. doi: 10.1097/00005176-199202000-00009.
Celiac disease (CD) is characterized by diarrhea, growth retardation, and weight loss in genetically susceptible subjects on a gluten-containing diet. The exact pathogenesis of CD is still obscure, but it is considered to be immunologically mediated. We have previously shown elevated prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) content in small intestinal mucosa obtained from active celiac children. In the present study, we found significantly elevated PGE2, leukotriene B4 (LTB4), and leukotrienes C4, D4, and E4 (LTC4D4E4) content in small bowel mucosa from children suffering from CD on a gluten-containing diet in comparison to control subjects. PGE2 was 25,278 +/- 7,761 vs. 4,478 +/- 426 pg/mg of protein (mean +/- SEM), respectively. LTB4 was 8,807 +/- 3,706 vs. 403 +/- 63 pg/mg of protein (mean +/- SEM), respectively. LTC4D4E4 was 15,369 +/- 4,085 vs. 2,998 +/- 279 pg/mg of protein (mean +/- SEM), respectively. We conclude that the elevated content of arachidonic acid metabolic products via cyclooxygenase and lipoxygenase pathways may contribute to the diarrhea and may be involved in the pathogenesis of mucosal injury.
乳糜泻（CD）的特征是，在食用含麸质饮食的遗传易感性个体中出现腹泻、生长发育迟缓及体重减轻。CD的确切发病机制仍不清楚，但被认为是免疫介导的。我们之前已表明，从患有活动期乳糜泻的儿童获取的小肠黏膜中，前列腺素E2（PGE2）和血栓素B2（TxB2）含量升高。在本研究中，我们发现，与对照受试者相比，食用含麸质饮食的CD患儿的小肠黏膜中，PGE2、白三烯B4（LTB4）以及白三烯C4、D4和E4（LTC4D4E4）含量显著升高。PGE2分别为25,278 +/- 7,761与4,478 +/- 426 pg/mg蛋白质（平均值 +/- 标准误）。LTB4分别为8,807 +/- 3,706与403 +/- 63 pg/mg蛋白质（平均值 +/- 标准误）。LTC4D4E4分别为15,369 +/- 4,085与2,998 +/- 279 pg/mg蛋白质（平均值 +/- 标准误）。我们得出结论，经由环氧化酶和脂氧化酶途径的花生四烯酸代谢产物含量升高，可能导致腹泻，并可能参与黏膜损伤的发病机制。
