Branski D, Karmeli F, Gross-Kieselstein E, Abrahamov A, Rachmilewitz D
J Pediatr Gastroenterol Nutr. 1984 Nov;3(5):672-5. doi: 10.1097/00005176-198411000-00005.
Diarrhea is one of the important clinical symptoms in patients suffering from celiac disease and is attributed mainly to malabsorption. We determined prostanoid content in small intestinal mucosa of five patients with active celiac disease and in a control group consisting of six patients. Prostaglandin E2 and thromboxane B2 content in duodenal mucosa of patients with active celiac disease was 1,581 +/- 161 and 118 +/- 40 pg/mg wet wt, respectively, significantly higher than their content in duodenal mucosa of the control group, 378 +/- 86 and 8 +/- 8, p less than 0.001 and p less than 0.02, respectively. 6-Ketoprostaglandin F1 alpha content in celiac patients was not significantly different from its content in the control group: 908 +/- 437 and 124 +/- 53 pg/mg wet wt, respectively. It is possible that, in celiac disease, increased mucosal prostanoid content may contribute, at least in part, to intestinal electrolyte and fluid secretion and consequent diarrhea.
腹泻是乳糜泻患者的重要临床症状之一，主要归因于吸收不良。我们测定了5例活动性乳糜泻患者以及由6例患者组成的对照组的小肠黏膜中类前列腺素含量。活动性乳糜泻患者十二指肠黏膜中前列腺素E2和血栓素B2含量分别为1581±161和118±40 pg/mg湿重，显著高于对照组十二指肠黏膜中的含量，分别为378±86和8±8，p值分别小于0.001和小于0.02。乳糜泻患者中6-酮前列腺素F1α含量与对照组无显著差异：分别为908±437和124±53 pg/mg湿重。在乳糜泻中，黏膜类前列腺素含量增加可能至少部分导致肠道电解质和液体分泌以及随之而来的腹泻。
