Miwa H, Beran M, Saunders G F
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Leukemia. 1992 May;6(5):405-9.
Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13. WT1 was expressed in 7 of 16 cases of acute lymphoblastic leukemia, 15 of 22 with acute myelogenous leukemia and 8 of 10 in blast crisis of chronic myelogenous leukemia. No detectable WT1 RNA was found in chronic leukemias, including chronic lymphocytic leukemia, plasma cell leukemia, hairy cell leukemia and chronic myelogenous leukemia in chronic phase. The expression pattern of WT1 in these human leukemia samples indicates the involvement of this gene in the early stage of hematological cell differentiation.
对70例患有各种类型人类白血病患者的白血病细胞进行了WT1基因表达检测，WT1基因即位于11号染色体p13位置的威尔姆斯瘤基因。在16例急性淋巴细胞白血病中有7例表达WT1，22例急性髓细胞白血病中有15例表达，10例慢性髓细胞白血病急变期中有8例表达。在慢性白血病中未检测到可检测到的WT1 RNA，包括慢性淋巴细胞白血病、浆细胞白血病、毛细胞白血病和慢性期慢性髓细胞白血病。WT1在这些人类白血病样本中的表达模式表明该基因参与了血液细胞分化的早期阶段。
