Rizzoni G, Ehrich J H, Broyer M, Brunner F P, Brynger H, Fassbinder W, Geerlings W, Selwood N H, Tufveson G, Wing A J
Ospedale Pediatrico Bambino Gesú, Istituto di Ricerca Scientifica, Roma, Italy.
Nephrol Dial Transplant. 1992;7(4):279-87. doi: 10.1093/oxfordjournals.ndt.a092129.
This study reports the geographical incidence of successful pregnancies in women on renal replacement therapy (RRT) and related information on gestation and clinical status of newborns. The impact of successful pregnancy on graft function was assessed by means of a retrospective case-control study. Since 1977 special questionnaires have been sent to each dialysis and transplant centre which reported babies born to mothers on RRT on the yearly centre questionnaire. After 10 years of data collection, a total of 490 pregnancies and 500 babies were available for analysis. A percentage of 88.4 of the babies were born to mothers with a functioning graft, 11.2% to mothers on chronic haemodialysis, and the remaining 0.4% to mothers on CAPD. Almost 50% of all successful pregnancies were reported from the UK. The number of successful pregnancies increased steadily and in parallel with the increasing number of females of childbearing age with a functioning renal transplant. The majority of mothers delivered at age 24-32. For transplanted mothers delivery occurred most commonly during the 3rd and 4th year after successful transplantation. In approximately 85% of cases the duration of pregnancy was shorter than the lower 10th percentile of normal. Birthweight was reduced in accordance with gestational age. Newborn mortality was 1.8%. Fifty-three mothers with a successful pregnancy in 1984-1987 were computer matched with controls according to a number of criteria. The serum creatinine concentration recorded in coded form at the end of each year on the individual EDTA patient questionnaire was used to assess changes in graft function.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究报告了接受肾脏替代治疗（RRT）的女性成功妊娠的地理发生率以及有关妊娠和新生儿临床状况的相关信息。通过回顾性病例对照研究评估成功妊娠对移植肾功能的影响。自1977年以来，已向每个透析和移植中心发送了特别问卷，这些中心在年度中心问卷中报告了接受RRT治疗的母亲所生的婴儿。经过10年的数据收集，共有490例妊娠和500名婴儿可供分析。88.4%的婴儿母亲有功能正常的移植肾，11.2%的婴儿母亲接受慢性血液透析，其余0.4%的婴儿母亲接受持续性非卧床腹膜透析（CAPD）。几乎50%的成功妊娠报告来自英国。成功妊娠的数量稳步增加，与有功能的肾移植的育龄女性数量增加同步。大多数母亲在24至32岁分娩。对于接受移植的母亲，分娩最常发生在成功移植后的第3年和第4年。在大约85%的病例中，妊娠持续时间短于正常妊娠的第10百分位数下限。出生体重根据孕周降低。新生儿死亡率为1.8%。根据多项标准，对1984年至1987年成功妊娠的53名母亲与对照组进行了计算机匹配。每年在个体乙二胺四乙酸（EDTA）患者问卷末尾以编码形式记录的血清肌酐浓度用于评估移植肾功能的变化。（摘要截短至250字）
