Pulkkinen M, Monti T, Macciocchi A
Department of Obstetrics and Gynecology, University of Turku, Finland.
Acta Obstet Gynecol Scand. 1992 Apr;71(3):181-5. doi: 10.3109/00016349209009915.
To study the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on uterine contractility in different parts of the uterus and on the direction and velocity of propagation of the activity, intra-uterine pressure (IUP) was measured simultaneously in 10 dysmenorrheic and 5 eumenorrheic patients with two microtransducer catheters at two locations (30 mm apart) before and after taking nimesulide, a newly developed NSAID. The uterus developed higher pressure cycles in the fundus than in the isthmus, in both eumenorrheic and dysmenorrheic conditions. Nimesulide did not affect either the active pressure (AP) or the direction and velocity of propagation of the activity, though it alleviated pain significantly. In dysmenorrheic patients, resting pressure (RP) is at a high level only in the fundus. The velocity of propagation ranged from 12 to 19 mm/s. The mathematical probability of procervical activity (1.0 if all procervical; 0.0 if all profundal), and thus the transport, was 0.59 in eumenorrheic and 0.68 in dysmenorrheic patients, the average for the whole series being 0.65. The luminal content (menstrual blood) moves in the cervical direction much more slowly than would be expected on the basis of simple calculations of velocity (velocity vector) of propagation.
为研究非甾体抗炎药（NSAIDs）对子宫不同部位子宫收缩力以及活动传播方向和速度的影响，在10例痛经患者和5例月经正常患者服用新研发的NSAIDs尼美舒利前后，使用两个微型换能器导管在两个位置（相距30毫米）同时测量子宫内压（IUP）。在月经正常和痛经情况下，子宫底部产生的压力周期均高于子宫峡部。尼美舒利虽能显著缓解疼痛，但对主动压力（AP）以及活动传播方向和速度均无影响。在痛经患者中，仅子宫底部的静息压力（RP）处于较高水平。传播速度范围为12至19毫米/秒。月经正常患者宫颈活动（若全为宫颈活动则为1.0；若全为深部活动则为0.0）以及由此而来的运输的数学概率为0.59，痛经患者为0.68，整个系列的平均值为0.65。管腔内容物（经血）向宫颈方向移动的速度比根据传播速度（速度矢量）简单计算预期的要慢得多。
