Armatage R J, Luckas M J
Liverpool Women's Hospital, United Kingdom.
Aust N Z J Obstet Gynaecol. 1996 Aug;36(3):296-9. doi: 10.1111/j.1479-828x.1996.tb02714.x.
The most frequently used method for second trimester termination of pregnancy is administration of gemeprost (16, 16-dimethyl-trans delta 2-prostaglandin E1methyl ester) as a vaginal pessary. This provides a safe and effective method for achieving abortion. The current prescribing advice is to insert the pessaries into the posterior vaginal fornix every 3 hours. This study compares this to a 6-hourly regimen. The median abortion interval in the 6-hour group was shorter than the 3-hour group (15 versus 16 hours respectively) but the cumulative abortion rates were similar (98% in the 3-hour group and 91.8% in the 6-hour group). The 6-hour group required a significantly lower total dose of gemeprost to induce abortion. There was no difference in the rates of side-effects in the 2 groups but those receiving pessaries every 6 hours required less analgesia. This study finds no advantage in giving gemeprost every 3 hours.
孕中期终止妊娠最常用的方法是使用吉美前列素（16,16 - 二甲基 - 反式δ2 - 前列腺素E1甲酯）作为阴道栓剂。这为实现流产提供了一种安全有效的方法。目前的处方建议是每3小时将栓剂插入阴道后穹窿。本研究将此与每6小时一次的给药方案进行比较。6小时组的中位流产间隔比3小时组短（分别为15小时和16小时），但累积流产率相似（3小时组为98%，6小时组为91.8%）。6小时组诱导流产所需的吉美前列素总剂量显著更低。两组的副作用发生率没有差异，但每6小时接受一次栓剂的患者所需的镇痛药物更少。本研究发现每3小时给予吉美前列素并无优势。
