Iglesias J G, Trujano M, Xu J
Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Am J Vet Res. 1992 Mar;53(3):364-7.
Pigs (9 [+/- 1] weeks old) were inoculated with Streptococcus suis type 2, pseudorabies virus (PRV), or both. For each pig of groups A, B, and C the inoculum of S suis was 10(9) colony-forming units. For each pig of groups A, B, and D the inoculum of PRV was 5 x 10(3) TCID50 of either PRV strain 4892 (group A, n = 9) or PRV isolate B (group B, n = 9). The PRV strain 4892 is a highly virulent strain; isolate B causes mild clinical signs of infection in inoculated pigs. Group-C pigs (n = 9) were given S suis alone, and group-D pigs (n = 3) were inoculated only with PRV isolate B. Clinical signs of infection and development of lesions were readily seen in pigs of groups A, B, and C. Duration and severity of clinical signs of disease and lesions were reduced in pigs of group C, compared with those of the other 2 groups. Lesions, such as polyarthritis and fibrinous pericarditis, were more abundant and acute in the groups of pigs given mixed challenge exposure, compared with pigs inoculated exclusively with S suis type 2 (group C). The group of pigs inoculated with PRV isolate B alone did not manifest clinical signs of disease or lesions. Average daily gain for group-C pigs was higher, compared with that of other groups; the difference was statistically significant at P less than 0.02 and P less than 0.05 for groups B and D, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
选用9（±1）周龄的猪，分别接种2型猪链球菌、伪狂犬病病毒（PRV）或两种病毒。A、B、C组每头猪接种的猪链球菌接种量为10⁹菌落形成单位。A、B、D组每头猪接种的PRV接种量为5×10³半数组织培养感染剂量（TCID₅₀），其中A组（n = 9）接种PRV毒株4892，B组（n = 9）接种PRV分离株B。PRV毒株4892是高毒株；分离株B在接种猪中引起轻度感染临床症状。C组猪（n = 9）仅接种猪链球菌，D组猪（n = 3）仅接种PRV分离株B。A、B、C组猪很容易出现感染临床症状和病变发展。与其他两组相比，C组猪疾病临床症状和病变的持续时间及严重程度有所减轻。与仅接种2型猪链球菌的猪（C组）相比，混合感染组猪的病变，如多关节炎和纤维素性心包炎，更丰富且更严重。仅接种PRV分离株B的猪组未出现疾病临床症状或病变。与其他组相比，C组猪的平均日增重更高；与B组和D组相比，差异分别在P<0.02和P<0.05时具有统计学意义。（摘要截短至250字）
