Rothstein J D, Guidotti A, Tinuper P, Cortelli P, Avoni P, Plazzi G, Lugaresi E, Schoch P, Montagna P
Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205.
Lancet. 1992 Oct 24;340(8826):1002-4. doi: 10.1016/0140-6736(92)93011-b.
"Endozepines" are endogenous ligands for the benzodiazepine recognition sites on gamma-aminobutyric acid A receptors in the nervous system. Idiopathic recurring stupor (IRS) is a syndrome of spontaneous stupor or coma that is not associated with known metabolic, toxic, or structural abnormalities but can be reversed by flumazenil, a pure benzodiazepine antagonist. We measured endozepine-2 and endozepine-4 by high-performance liquid chromatography and radioreceptor assay in serum and cerebrospinal fluid from three patients with IRS. During episodes of stupor there was a large (up to 300-fold compared with control patients) increase of endozepine-4 content in cerebrospinal fluid and serum, but a return to normal concentrations between attacks. Endozepine-4 may contribute to, or be the cause of, IRS. The reasons for abnormal concentrations of endozepine in blood and brain are unknown.
“内源性苯二氮䓬类物质”是神经系统中γ-氨基丁酸A受体上苯二氮䓬类识别位点的内源性配体。特发性反复性木僵（IRS）是一种自发的木僵或昏迷综合征，与已知的代谢、毒性或结构异常无关，但可被氟马西尼（一种纯苯二氮䓬类拮抗剂）逆转。我们通过高效液相色谱法和放射受体分析法，对3例IRS患者的血清和脑脊液中的内源性苯二氮䓬类物质-2和内源性苯二氮䓬类物质-4进行了测量。在木僵发作期间，脑脊液和血清中的内源性苯二氮䓬类物质-4含量大幅增加（与对照患者相比高达300倍），但发作间期恢复到正常浓度。内源性苯二氮䓬类物质-4可能促成IRS或为其病因。血液和大脑中内源性苯二氮䓬类物质浓度异常的原因尚不清楚。
