Mauriège P, Després J P, Marcotte M, Tremblay A, Nadeau A, Moorjani S, Lupien P, Dussault J, Fournier G, Thériault G
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.
Int J Obes Relat Metab Disord. 1992 Mar;16(3):219-25.
Ten pairs of young male sedentary, non-obese, monozygotic (MZ) twins, aged 21 +/- 2 years (mean +/- s.d.), were overfed for a period of 100 days during which they ingested 4.2 MJ (1000 kcal) per day above their individual energy needs, 6 days per week. There was a mean 8.4 kg increase in body weight and the average gain in body fat reaches 5.6 kg (P less than 0.0001). A biopsy of subcutaneous abdominal fat was performed, before and after the treatment, to determine fat cell weight as well as basal and catecholamine stimulated lipolyses from collagenase isolated adipocytes. Although analysis of variance revealed an increase in abdominal fat cell weight, no significant changes were noted in basal and catecholamine-stimulated lipolyses, due to large variation among individuals, results being expressed either per cell number or corrected for cell surface area. However, significant intrapair resemblance was observed in the changes of basal and epinephrine stimulated lipolyses (ri of about 0.60 in both cases), suggesting a concordant within-pair response, despite large between-pair variation. These results support the notion that the genotype may play an important role in regulating the response of abdominal adipose cells lipolytic activity to caloric excess.
十对年轻的久坐不动、非肥胖的同卵（MZ）双胞胎男性，年龄为21±2岁（平均±标准差），在100天的时间里过度喂养，在此期间他们每周6天每天摄入比个人能量需求多4.2兆焦耳（1000千卡）的热量。体重平均增加了8.4千克，体脂平均增加达到5.6千克（P<0.0001）。在治疗前后进行腹部皮下脂肪活检，以确定脂肪细胞重量以及从胶原酶分离的脂肪细胞的基础和儿茶酚胺刺激的脂解作用。尽管方差分析显示腹部脂肪细胞重量增加，但由于个体间差异较大，无论是按细胞数量还是校正细胞表面积来表示结果，基础和儿茶酚胺刺激的脂解作用均未发现显著变化。然而，在基础和肾上腺素刺激的脂解作用变化中观察到了显著的同对内相似性（两种情况下的ri约为0.60），这表明尽管对间差异较大，但同对内反应一致。这些结果支持了基因型可能在调节腹部脂肪细胞脂解活性对热量过剩的反应中起重要作用这一观点。
