Nivsarkar M, Kumar G P, Laloraya M, Laloraya M M
School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India.
Arch Insect Biochem Physiol. 1992;19(4):261-70. doi: 10.1002/arch.940190405.
The present study documents that the secondary plant metabolites, especially alpha-terthienyl, exert phototoxic action through inhibition of certain enzymes and generation of singlet oxygen. Some of the reports have emerged exhibiting involvement of free radical generation in vitro by alpha-terthienyl. We provide evidence for the generation of a free radical viz., superoxide anion radical, by alpha-terthienyl employing spin-trapping techniques, probably due to the extension of the latter reaction. On the basis of this observation the phototoxic action of alpha-terthienyl on Aedes aegypti larvae is explained.
本研究证明，植物次生代谢产物，尤其是α-三联噻吩，通过抑制某些酶和产生单线态氧发挥光毒性作用。一些报告显示α-三联噻吩在体外可产生自由基。我们利用自旋捕获技术提供了α-三联噻吩产生自由基即超氧阴离子自由基的证据，这可能是由于后一反应的延伸。基于这一观察结果，解释了α-三联噻吩对埃及伊蚊幼虫的光毒性作用。
