（1H-茚基）噻吩的光毒性

Phototoxicity of (1H-indenyl)thiophenes.

作者信息

Herrnreiter M, Kagan J, Chen X, Lau K Y, D'Auria M, Vantaggi A

机构信息

Department of Chemistry, University of Illinois, Chicago 60607.

出版信息

Photochem Photobiol. 1993 Jul;58(1):49-52. doi: 10.1111/j.1751-1097.1993.tb04902.x.

DOI:10.1111/j.1751-1097.1993.tb04902.x

PMID:8378432

Abstract

The (1H-indenyl)thiophene derivatives 2 and 3 were recently reported to be excellent singlet oxygen sensitizers, comparable to alpha-terthienyl (1). The phototoxicity of these compounds was compared, using human erythrocytes, Aedes aegypti mosquito larvae, Daphnia magna, and fish (fathead minnows, Pimephales promelas). The known ranking of the photooxidation properties was found to be a good predictor of phototoxic properties in erythrocytes and mosquito larvae but not in daphnias. All three compounds photosensitized the cleavage of supercoiled pBR322 DNA to the same extent.

摘要

据最近报道，（1H-茚基）噻吩衍生物2和3是出色的单线态氧敏化剂，可与α-三联噻吩（1）相媲美。使用人类红细胞、埃及伊蚊幼虫、大型溞和鱼类（黑头呆鱼，肥头鲦鱼）比较了这些化合物的光毒性。已知的光氧化特性排名被发现是红细胞和蚊虫幼虫光毒性特性的良好预测指标，但在大型溞中并非如此。所有三种化合物对超螺旋pBR322 DNA的切割光敏化程度相同。