Depression and neurological disease. Their distinction and association.

Depression and neurological disease often coexist but sometimes are difficult to distinguish. By analyzing eight patients, all seen by psychiatrists and the same neurologist, and by reviewing the pertinent literature, we will explore the complex differential features, coexistence, and interaction between depression and neurological disease. Neurological disease may lead to changes in mood and behavior, and these patients may present to psychiatrists with depression. In addition, depression may present with or exaggerate neurological signs and symptoms. Awareness of these interactions can lead to appropriate evaluation and treatment of both these disorders.