SCHWAB M P, FOX J P, CONWELL D P, ROBINSON T A
Bull World Health Organ. 1954;10(5):823-35.
This paper describes the results of three experiments in which 98 volunteers were inoculated intramuscularly with living avianized rabies virus of the Flury strain, modified by adaptation to chick embryo; their reactions were compared with those of 31 other persons either inoculated with normal-embryo material, or undergoing Pasteur treatment. Immune response was estimated by determination of the development of neutralizing antibodies. These observations show that Flury-virus vaccine can be used without untoward effects for the immunization of man against rabies, but give no clear indication as to the best method for the administration of this vaccine.
本文描述了三项实验的结果。在这些实验中,98名志愿者通过肌肉注射接种了经鸡胚适应改良的弗吕里株活禽化狂犬病病毒;将他们的反应与另外31名接种正常胚胎物质或接受巴斯德疗法的人的反应进行了比较。通过测定中和抗体的产生来评估免疫反应。这些观察结果表明,弗吕里病毒疫苗可用于人类狂犬病免疫且无不良影响,但未明确指出该疫苗的最佳接种方法。