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刺激频率与输精管在不同温度下对电刺激的双相反应各成分相对大小之间的关系。

The relation between stimulus frequency and the relative size of the components of the biphasic response of the vas deferens to electrical stimulation at different temperatures.

作者信息

Birmingham A T, Freeman M A

出版信息

J Physiol. 1976 Apr;256(3):747-59. doi: 10.1113/jphysiol.1976.sp011349.

DOI:10.1113/jphysiol.1976.sp011349
PMID:131853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1309335/
Abstract
  1. Electrical stimulation of the guinea-pig or rat vas deferens (pre- or post-ganglionically) at frequencies from 2-5 to 40 Hz with trains of stimuli of 30 sec duration induced a biphasic response. A rapid contraction (component A) was followed after a brief relaxation by a slower contraction (component B); the two phases were seen most clearly with stimulation frequencies of less than 10 Hz. 2. The responses to post-ganglionic stimulation were always larger than those to preganglionic stimulation. In general, at low frequencies component A exceeded component B whilst at high frequencies component B was the larger. Separation of the two components on the basis of their frequency response characteristics was better for rat than for guinea-pig vasa. 3. Log. frequency-response curves to transmural (post-ganglionic) electrical stimulation and log dose-response curves to noradrenaline were recorded for guinea-pig and rat vasa deferentia at 32 degrees, 22 degrees and 12 degrees C. For the guinea-pig reduction of bath temperature to 12 degrees C increased the amplitude of component A at 2-5 and 5 Hz; component B could not confidently be distinguished at this temperature. At 22 degrees C there was potentiation of B at lower frequencies and depression of B at higher frequencies. There was no response to noradrenaline at 12 degrees C. At 22 degrees C the response to noradrenaline was increased except to doses at or near the maximum to which the response was reduced. 4. For the rat was deferens component A was little changed by reduction of temperature. Component B at 12 degrees C was greatly depressed at higher frequencies. The response to noradreanaline was increased to lower doses and decreased to higher doses as the temperature was lowered. 5. The B component of the response of guinea-pig vasa at 22 degrees C and rat vasa at 32 degrees C was more sensitive than the A component to inhibition by thymoxamine. 6. Further analysis of the mechanisms underlying the A and B components of the biphasic response may be facilitated by relative isolation of each component by the appropriate selection of parameters of electrical stimulation and of temperature for the species being investigated. The contractions of the B component are similar to, if not identical with, those produced by exogenously applied noradrenaline.
摘要
  1. 以2 - 5至40赫兹的频率、持续30秒的刺激串对豚鼠或大鼠输精管进行节前或节后电刺激,会诱发双相反应。先是快速收缩(A成分),短暂松弛后接着是较慢的收缩(B成分);刺激频率低于10赫兹时,这两个阶段最为明显。2. 节后刺激的反应总是大于节前刺激的反应。一般来说,低频时A成分超过B成分,而高频时B成分更大。基于频率反应特性分离这两个成分,大鼠输精管比豚鼠输精管效果更好。3. 在32℃、22℃和12℃下,记录了豚鼠和大鼠输精管对经壁(节后)电刺激的对数频率反应曲线以及对去甲肾上腺素的对数剂量反应曲线。对于豚鼠,将浴温降至12℃会增加2 - 5赫兹和5赫兹时A成分的幅度;在此温度下无法确切区分B成分。在22℃时,较低频率下B成分增强,较高频率下B成分减弱。在12℃时对去甲肾上腺素无反应。在22℃时,除了接近最大反应剂量或最大反应剂量时反应降低外,对去甲肾上腺素的反应增强。4. 对于大鼠输精管,温度降低时A成分变化不大。在12℃时,较高频率下B成分大幅减弱。随着温度降低,对去甲肾上腺素的反应在较低剂量时增强,在较高剂量时减弱。5. 22℃时豚鼠输精管反应的B成分和32℃时大鼠输精管反应的B成分比A成分对噻吗心安的抑制更敏感。6. 通过为所研究的物种适当选择电刺激参数和温度,相对分离双相反应的A和B成分,可能有助于进一步分析其潜在机制。B成分的收缩即使不完全相同,也与外源性应用去甲肾上腺素产生的收缩相似。

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本文引用的文献

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MECHANISM OF ADRENERGIC STIMULATION OF MAMMALIAN ARTERIES AND ITS FAILURE AT LOW TEMPERATURES.哺乳动物动脉肾上腺素刺激机制及其在低温下的失效
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The effect of local anaesthetic and anti-adrenaline drugs on the response of sympathetically innervated smooth muscle preparations to electrical stimulation at different frequencies.局部麻醉药和抗肾上腺素药物对交感神经支配的平滑肌制剂在不同频率电刺激下反应的影响。
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3 H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens.3H-去甲肾上腺素在电场刺激的小鼠输精管中的释放及机械反应
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Evidence against adrenergic motor transmission in the guinea-pig vas deferens.豚鼠输精管中肾上腺素能运动传递的反证。
J Physiol. 1971 Jul;216(2):359-89. doi: 10.1113/jphysiol.1971.sp009530.
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Biphasic mechanical response of the isolated vas deferens to nerve stimulation.离体输精管对神经刺激的双相机械反应。
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