Iwai T, Niwa M, Nakashima M, Kambara T, Yamada H, Tsurumi K, Nozaki M
Department of Neurosurgery, Gifu University School of Medicine, Japan.
Life Sci. 1992;50(26):PL239-44. doi: 10.1016/0024-3205(92)90580-i.
The effect of opioids on delayed neuronal death was evaluated in the gerbil hippocampus. Male Mongolian gerbils were subjected to transient forebrain ischemia and neuronal density was evaluated in the hippocampus 7 days following ischemia. When hypothermia during and after ischemia was prevented, treatment with morphine, U-50488H, or naloxone provided no significant protection. In contrast, a spontaneous drop in rectal temperature to 32 degrees C at the end of ischemia produced near-complete protection of CA1 pyramidal neurons. No opioids modulate the protective effect of hypothermia.
在沙鼠海马体中评估了阿片类药物对迟发性神经元死亡的影响。雄性蒙古沙鼠经历短暂性前脑缺血，并在缺血后7天评估海马体中的神经元密度。当缺血期间和之后的体温过低被阻止时，用吗啡、U-50488H或纳洛酮治疗没有提供显著的保护作用。相比之下，缺血结束时直肠温度自发降至32摄氏度对CA1锥体神经元产生了近乎完全的保护作用。没有阿片类药物能调节体温过低的保护作用。
