Silvia R C, Slizgi G R, Ludens J H, Tang A H
Brain Res. 1987 Feb 10;403(1):52-7. doi: 10.1016/0006-8993(87)90121-1.
U-50488 is a specific kappa opioid agonist which produces in rats water diuresis resulting in an elevation of plasma osmolarity. Pretreatment with U-50488H (the methanesulfonate salt) in Fisher rats prior to 4 h of bilateral carotid occlusion prevented the development of edema in the forebrain, and the effect was greater than that from pentobarbital anesthesia. An additional injection of an antidiuretic hormone which prevented the plasma hyperosmolarity also significantly reduced the anticerebral edemic effects of U-50488H. The plasma osmotic effect, however, may not completely account for the ischemic protection produced by U-50488H.
U - 50488是一种特异性κ阿片受体激动剂，它在大鼠体内可产生水利尿作用，导致血浆渗透压升高。在双侧颈动脉闭塞4小时之前，用U - 50488H（甲磺酸盐）对费希尔大鼠进行预处理，可预防前脑水肿的发生，且该效果比戊巴比妥麻醉的效果更显著。额外注射一种抗利尿激素，可防止血浆渗透压升高，这也显著降低了U - 50488H的抗脑水肿作用。然而，血浆渗透效应可能无法完全解释U - 50488H所产生的缺血保护作用。
