细胞色素c氧化酶亚基IV的人类基因的快速进化。

Rapid evolution of the human gene for cytochrome c oxidase subunit IV.

作者信息

Lomax M I, Hewett-Emmett D, Yang T L, Grossman L I

机构信息

Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor 48109.

出版信息

Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5266-70. doi: 10.1073/pnas.89.12.5266.

DOI:10.1073/pnas.89.12.5266

PMID:1319058

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC49272/

Abstract

We have compared the DNA sequences of nine mammalian genes for cytochrome c oxidase subunit IV (COX4 genes)--four expressed genes (human, bovine, rat, and mouse) and five pseudogenes (human, chimpanzee, orangutan, squirrel monkey, and bovine)--and constructed the sequence of the ancestral mammalian COX4 gene. By analyzing these sequences to determine the pattern and rate of nucleotide substitution in each branch of the evolutionary tree, we deduced that the human gene has evolved rapidly since the origin of the primate pseudogene approximately 41 million years ago, and we discuss the suggestion that this results from coevolution of nuclear and mitochondrial genes for cytochrome c oxidase.

摘要

我们比较了九个哺乳动物细胞色素c氧化酶亚基IV基因（COX4基因）的DNA序列——四个表达基因（人类、牛、大鼠和小鼠）和五个假基因（人类、黑猩猩、猩猩、松鼠猴和牛），并构建了哺乳动物祖先COX4基因的序列。通过分析这些序列以确定进化树每个分支中的核苷酸替换模式和速率，我们推断自大约4100万年前灵长类假基因起源以来，人类基因进化迅速，并且我们讨论了这是由细胞色素c氧化酶的核基因和线粒体基因共同进化导致的这一观点。