Gloor M, Habedank W D
MMW Munch Med Wochenschr. 1976 May 14;118(20):649-52.
Stickl's method of oral treatment of acne vulgaris with antigens has been carried out on 26 test persons. During the treatment the number of comedones increased significantly and the number of papules decreased significantly. Biochemically, a significant increase of the free fatty acids and a significant decrease of the triglycerides could be demonstrated in the skin surface lipids, the total amount remaining unchanged. The following important conclusions for the pathogenesis of acne may be drawn: 1. The living conditions for Corynebacterium acnes on the surface of the skin or in the ducts of sebaceous glands respectively are influenced by the immunological system of the host. 2. The free fatty acids have a comedogenic effect in vivo. 3. The free fatty acids are not responsible for the development of inflammatory acne efflorescences.
施蒂克尔用抗原口服治疗寻常痤疮的方法已在26名受试者身上进行。治疗期间，粉刺数量显著增加，丘疹数量显著减少。生化方面，皮肤表面脂质中游离脂肪酸显著增加，甘油三酯显著减少，总量保持不变。对于痤疮的发病机制可得出以下重要结论：1. 痤疮丙酸杆菌在皮肤表面或皮脂腺导管中的生存条件分别受宿主免疫系统影响。2. 游离脂肪酸在体内有致粉刺作用。3. 游离脂肪酸与炎性痤疮皮疹的发生无关。
