Ehymayed H M, Janský L
Department of Comparative Physiology, Faculty of Science, Charles University, Prague.
Physiol Res. 1992;41(1):57-61.
The antipyretic effect of AVP, alpha-MSH and ACTH consists in lowering the thermoregulatory threshold and in shortening the time span of the fever. Thus, neuropeptides influence activity of hypothalamic neurones regulating body temperature. This was confirmed by recent experiments of Moravec (this volume) which indicate that spontaneous activity and thermosensitivity of neurones in hypothalamic slices can be influenced, by AVP. Why neuropeptides of different chemical structure such as AVT, on one hand, and alpha-MSH and ACTH, on the other hand, induce the same effect on thermoregulation remains to be elucidated.
抗利尿激素（AVP）、α-促黑素（α-MSH）和促肾上腺皮质激素（ACTH）的解热作用在于降低体温调节阈值并缩短发热的持续时间。因此，神经肽会影响调节体温的下丘脑神经元的活动。莫拉韦克（本卷）最近的实验证实了这一点，这些实验表明抗利尿激素可影响下丘脑切片中神经元的自发活动和热敏感性。为何化学结构不同的神经肽，一方面是抗利尿激素（AVT），另一方面是α-促黑素和促肾上腺皮质激素，会对体温调节产生相同的作用仍有待阐明。
