Horowitz M, Epstein Y, Shapiro Y
Department of Physiology, Hadassah School of Dental Medicine, Hebrew University, Jerusalem, Israel.
Physiol Res. 1992;41(1):41-8.
Previous studies have substantiated the antipyretic role played by extrahypothalamic limbic system (EXHY-LS) AVP during fever. Repeated attempts to elucidate other thermoregulatory functions of this hormone have failed. Circumstantial evidence, however, suggest central role for this hormone in thermoregulation under hypohydration. Hypohydration, hyperosmolarity and hypovolaemia induced upward shifts in temperature thresholds for activation of heat dissipating mechanisms. When hypovolaemia is superimposed on hyperosmolarity these shifts are additive. Analogously, these two stressors when combined, decrease the osmotic threshold for AVP release. In rats, the elevated temperature thresholds for evaporative cooling and peripheral vasodilation occurring with hypohydration are positively correlated with lower Hypothalamic/EXHY-LS AVP ratio. Reciprocal relations between limbic system and blood AVP contents suggest competitive interaction between central and peripheral demands. Hypothesis for the possible mode of action of central AVP in thermoregulation under hypohydration is discussed.
先前的研究证实了下丘脑外边缘系统（EXHY-LS）抗利尿激素（AVP）在发热期间所起的解热作用。人们多次试图阐明这种激素的其他体温调节功能，但均未成功。然而，间接证据表明该激素在低水合状态下的体温调节中起核心作用。低水合、高渗和低血容量会导致激活散热机制的温度阈值上移。当低血容量叠加在高渗状态上时，这些变化是相加的。类似地，这两种应激源结合时，会降低AVP释放的渗透压阈值。在大鼠中，低水合时发生的蒸发散热和外周血管舒张的温度阈值升高与下丘脑/EXHY-LS AVP比值降低呈正相关。边缘系统与血液中AVP含量之间的相互关系表明中枢和外周需求之间存在竞争性相互作用。本文讨论了低水合状态下中枢AVP在体温调节中可能的作用方式的假说。
