Large scale preparation strategy for labelling of [123I]-SCH 23982, a dopamine D1 receptor binding agent.
作者信息
Beer H F, Lin S, Novak-Hofer I, Bläuenstein P, Schubiger P A
机构信息
Paul Scherrer Institute, Radiopharmacy Division, Villigen PSI, Switzerland.
出版信息
Int J Rad Appl Instrum A. 1992 Jun;43(6):781-7. doi: 10.1016/0883-2889(92)90242-7.
PMID:1319421
Abstract
The labelling of the D1 antagonist SCH 23982 with 123I was studied in detail by following the nucleophilic and electrophilic approaches and the reaction conditions were optimized. The product was purified by reversed phase HPLC with a phosphoric acid/EtOH mixture which simply has to be neutralized and diluted before injection. Its binding was tested in vitro with rat striatal membranes proving the high affinity to D1 and very low affinity to D2 receptors.
摘要
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