123I-SCH 23982不适用于人脑活体中的多巴胺D1受体成像。
123I-SCH 23982 is not suitable for dopamine D1 receptor imaging in vivo in the human brain.
作者信息
Verhoeff N P, Bekier A, Beer H F, Schubiger P A, Fennema P, van Royen E A
机构信息
Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
出版信息
Nucl Med Commun. 1993 Feb;14(2):137-44. doi: 10.1097/00006231-199302000-00012.
The tracer 123I-SCH 23982 was tested with regard to its ability to image dopamine D1 receptor in the human brain in vivo with single photon emission computed tomography (SPECT). The tracer did not reach equilibrium with regard to its binding to dopamine D1 receptors, presumably owing to fast metabolism to hydrophilic products and deiodination. It is concluded that 123I-SCH 23982 is not suitable for dopamine D1 receptor imaging with SPECT in the human brain.
用单光子发射计算机断层扫描（SPECT）对示踪剂123I-SCH 23982在人体内成像多巴胺D1受体的能力进行了测试。该示踪剂在与多巴胺D1受体结合方面未达到平衡，推测是由于其快速代谢为亲水性产物并发生脱碘。得出的结论是，123I-SCH 23982不适用于在人脑内用SPECT进行多巴胺D1受体成像。
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