Morton J L, Davenport M, Beloff-Chain A, Bodkin N L, Hansen B C
Clore Laboratory for the Biological Sciences, University of Buckingham, United Kingdom.
Am J Physiol. 1992 Jun;262(6 Pt 1):E963-7. doi: 10.1152/ajpendo.1992.262.6.E963.
The fasting plasma concentration of the pituitary peptide beta-cell tropin [beta-CT, adrenocorticotropic hormone-(22-39)] was measured in 17 rhesus monkeys from a colony known to develop spontaneous obesity. The weight of the animals was 9.4-23.9 kg (12-46% body fat). Plasma beta-CT concentrations were 0.03-0.84 nmol/l and were strongly correlated with body weight (P = 0.014, r = 0.584). Plasma beta-CT was also correlated with plasma insulin concentration as a power function (P = 0.011, r = 0.600) and with percent body fat up to 40% (P = 0.003, r = 0.0804). Plasma insulin is also correlated with body weight (P = 0.015, r = 0.578) but does not decline when body fat is in excess of 40%, supporting the hypothesis that beta-CT may be involved in a feed-back control mechanism, perhaps mediated by insulin. Because beta-CT has been shown in rodent studies to be a potent insulin secretagogue and lipogenic agent, it is possible that beta-CT is causally involved in the development of obesity and that there may be central determinants of obesity mediated through pituitary secretion of beta-CT.
在一群已知会发生自发性肥胖的恒河猴中，对17只恒河猴的垂体肽β细胞促生长素[β-CT，促肾上腺皮质激素-(22-39)]的空腹血浆浓度进行了测量。这些动物的体重为9.4-23.9千克（体脂率为12%-46%）。血浆β-CT浓度为0.03-0.84纳摩尔/升，与体重密切相关（P = 0.014，r = 0.584）。血浆β-CT还与血浆胰岛素浓度呈幂函数相关（P = 0.011，r = 0.600），与高达40%的体脂百分比相关（P = 0.003，r = 0.600）。血浆胰岛素也与体重相关（P = 0.015，r = 0.578），但当体脂超过40%时不会下降，这支持了β-CT可能参与反馈控制机制的假设，也许是由胰岛素介导的。因为在啮齿动物研究中已表明β-CT是一种有效的胰岛素促分泌剂和脂肪生成剂，所以β-CT可能因果性地参与肥胖的发生发展，并且可能存在通过垂体分泌β-CT介导的肥胖的中枢决定因素。
