多个序列元件参与脾脏坏死病毒的RNA 3'端形成。
Multiple sequence elements are involved in RNA 3' end formation in spleen necrosis virus.
作者信息
Iwasaki K, Temin H M
机构信息
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
出版信息
Gene Expr. 1992;2(1):7-18.
Abstract
The function of the poly(A) signal in spleen necrosis virus (SNV) is dependent upon the distance between the cap site and the poly(A) site, while the function of the SV40 late poly(A) signal is independent of the distance. Deletions in the SNV poly(A) sequence do not alter the distance-dependent function. SNV/SV40 chimeric poly(A) signals show intermediate behavior between the SNV and SV40 poly(A) signals. These results indicate that multiple sequence elements are involved in the functions of either the SNV or SV40 poly(A) signals. This intermediate behavior is also observed with poly(A) signals from the mouse alpha-globin and herpes simplex virus thymidine kinase genes.
摘要
脾坏死病毒（SNV）中聚腺苷酸化（poly(A)）信号的功能取决于帽位点与聚腺苷酸化位点之间的距离，而猴空泡病毒40（SV40）晚期聚腺苷酸化信号的功能则与该距离无关。SNV聚腺苷酸化序列中的缺失不会改变距离依赖性功能。SNV/SV40嵌合聚腺苷酸化信号表现出介于SNV和SV40聚腺苷酸化信号之间的中间行为。这些结果表明，多个序列元件参与了SNV或SV40聚腺苷酸化信号的功能。从小鼠α-珠蛋白和单纯疱疹病毒胸苷激酶基因的聚腺苷酸化信号中也观察到了这种中间行为。
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