Gu F
Institute of Urology, Beijing Medical University.
Zhonghua Yi Xue Za Zhi. 1992 Mar;72(3):135-7, 189.
The renotropic growth factor (RGF) does increase in postuninephrectomy serum although the majority of studies were conducted in experiment. As regard to whether there is postnephrectomy RGF in human being, we have not hitherto reached a conclusion. By incorporating tritiated thymidine (3H-TdR) into primary human kidney cells in culture. We have determined renotropic activity in the sera of 35 uninephrectomy patients. The RGF was found increased in 68% and 76% patients at postnephrectomy days 2 and 5 respectively, showing an average increase of 14% and 33% as compared with that of preoperation level. i.e. The RGF does exist in the sera of uninephrectomy patients. Through multifactorial analysis, it revealed that renotropic activity was higher in male and uninephrectomy patient with better renal function. The same was also found in the patient who had not encountered side effect derived from blood transfusion and that the kidney lesion was benign in nature. Female or senile patient with deteriorated renal function or those with malignant lesion or transfusion side effect showed a lower renotropic activity. But no significant statistic difference was seen between the two categories.
虽然大多数研究是在实验中进行的，但肾营养生长因子（RGF）在单侧肾切除术后的血清中确实会增加。关于人类单侧肾切除术后是否存在RGF，我们迄今尚未得出结论。通过将氚标记的胸腺嘧啶核苷（3H-TdR）掺入培养的原代人肾细胞中，我们测定了35例单侧肾切除患者血清中的肾营养活性。结果发现，分别在单侧肾切除术后第2天和第5天，68%和76%的患者RGF升高，与术前水平相比，平均升高14%和33%。即单侧肾切除患者的血清中确实存在RGF。通过多因素分析发现，男性以及肾功能较好的单侧肾切除患者的肾营养活性较高。在未出现输血副作用且肾脏病变为良性的患者中也发现了同样的情况。而肾功能恶化的女性或老年患者、患有恶性病变或有输血副作用的患者，其肾营养活性较低。但两类患者之间未发现显著的统计学差异。
