Obernauerová M, Subík J, Ebringer L
Department of Microbiology and Virology, Comenius University, Bratislava, Czechoslovakia.
Curr Genet. 1992 May;21(6):443-6. doi: 10.1007/BF00351653.
Ofloxacin, a new quinolone with potent antibacterial activity, was also found to be effective against yeast. At relatively high concentrations, and at mild alkaline pH, ofloxacin inhibited the growth of yeast cells in medium containing glucose, and prevented growth on glycerol, as carbon and energy source. The cells growing in the presence of ofloxacin exhibited abberrantly budded forms, lost their viability and many of them converted to cytoplasmic respiration-deficient mutants. Induction of mutants was also observed under non-growing conditions. The petite clones analysed exhibited suppressiveness and contained different fragments of the wild-type mitochondrial genome.
氧氟沙星是一种具有强大抗菌活性的新型喹诺酮类药物，也被发现对酵母有效。在相对较高的浓度和轻度碱性pH条件下，氧氟沙星抑制含葡萄糖培养基中酵母细胞的生长，并阻止其利用甘油作为碳源和能源生长。在有氧氟沙星存在的情况下生长的细胞呈现出异常出芽的形态，失去活力，其中许多细胞转变为细胞质呼吸缺陷型突变体。在非生长条件下也观察到了突变体的诱导。分析的小菌落克隆表现出抑制性，并包含野生型线粒体基因组的不同片段。
