Zwilling B S, Lafuse W P, Brown D, Pearl D
Department of Microbiology, Ohio State University Columbus 43120-1292.
J Neuroimmunol. 1992 Jul;39(1-2):133-8. doi: 10.1016/0165-5728(92)90182-k.
The effect of ACTH on the expression of major histocompatibility complex (MHC) class II (I-A) glycoprotein by murine peritoneal macrophages was evaluated. ACTH suppressed the expression of I-A by macrophages in a time- and dose-dependent manner. ACTH mediated its effect by decreasing the level of I-A mRNA. ACTH suppressed the expression of I-A by macrophages from mice that are susceptible to the in vivo growth of mycobacteria but did not affect the expression of I-A by macrophages from Mycobacterium bovis strain (BCG)-resistant mice. The concentrations of ACTH required to suppress I-A expression were greater than that required for an effect on adrenal steroid production and may be related to the localized production of ACTH by lymphocytes and macrophages.
评估了促肾上腺皮质激素（ACTH）对小鼠腹腔巨噬细胞主要组织相容性复合体（MHC）II类（I-A）糖蛋白表达的影响。ACTH以时间和剂量依赖的方式抑制巨噬细胞I-A的表达。ACTH通过降低I-A mRNA水平介导其作用。ACTH抑制了对分枝杆菌体内生长敏感小鼠的巨噬细胞I-A的表达，但不影响来自牛分枝杆菌菌株（卡介苗）抗性小鼠的巨噬细胞I-A的表达。抑制I-A表达所需的ACTH浓度高于对肾上腺类固醇产生影响所需的浓度，这可能与淋巴细胞和巨噬细胞局部产生ACTH有关。
