Zwilling B S, Dinkins M, Christner R, Faris M, Griffin A, Hilburger M, McPeek M, Pearl D
Department of Microbiology, Ohio State University, Columbus 43210-1292.
J Neuroimmunol. 1990 Sep-Oct;29(1-3):125-30. doi: 10.1016/0165-5728(90)90154-f.
The macrophage plays a central role in the development of immune responses. Macrophages take up and process antigen which is presented to antigen-responsive T lymphocytes in association with major histocompatibility complex class II (Ia) glycoproteins. We have investigated the effect of restraint stress on Ia expression by murine peritoneal macrophages. Stress resulted in a suppression of Ia expression which coincided with an increase in plasma corticosterone levels. In vitro experiments indicate that suppression of Ia expression can occur within 2 h after exposure to corticosterone. The suppression of this important aspect of macrophage function by stressors has important implications regarding the possible immunosuppressive effects of stress on the response of lymphocytes to antigens that depend on intact macrophage function.
巨噬细胞在免疫反应的发展中起核心作用。巨噬细胞摄取并处理抗原，该抗原与主要组织相容性复合体II类（Ia）糖蛋白一起呈递给抗原反应性T淋巴细胞。我们研究了束缚应激对小鼠腹腔巨噬细胞Ia表达的影响。应激导致Ia表达受到抑制，这与血浆皮质酮水平升高同时发生。体外实验表明，暴露于皮质酮后2小时内即可发生Ia表达的抑制。应激源对巨噬细胞功能这一重要方面的抑制，对于应激可能对依赖完整巨噬细胞功能的淋巴细胞对抗原反应产生的免疫抑制作用具有重要意义。
